References for the Functions of MBET Patented Natural Marine Extract

Our marine extracts have been documented in white papers based on peer-reviewed studies to have a wide range of benefits. These included helping rejuvenate skin, helping heal damaged skin and providing anti-inflammatory, anti-microbial and anti-cancer properties.

Rejuvenation

The ingredients of MBET Natural Marine Extract™ stimulate the cells to produce the components needed to rejuvenate the skin.

Thaweekitphathanaphakdee S, Chanvorachote P, Prateepchinda S, Khongkow M, Sucontphunt A. Abalone Collagen Extracts Potentiate Stem Cell Properties of Human Epidermal Keratinocytes. Mar Drugs. 2019 Jul 20;17(7):424. doi: 10.3390/md17070424. PMID: 31330853; PMCID: PMC6669461.

Wound Healing

Ingredients found in MBET’s patented Natural Marine Extract have been found to aid in all phases of wound healing including neovascularization, re-epithelialization and formation of granulation tissue.

Lalzawmliana, V., Mukherjee, P., Roy, S., Nandi, S.K. (2023). Current Marine-Derived Materials for Tissue Regeneration Applications. Maia, F.R.A., Oliveira, J.M., Reis, R.L. (eds) Handbook of the Extracellular Matrix. Springer, Cham. https://doi.org/10.1007/978-3-030-92090-6_52-1

Zhihong Zheng, Mengqi Li, Pengfei Jiang, Na Sun, Songyi Lin, Peptides derived from sea cucumber accelerate cells proliferation and migration for wound healing by promoting energy metabolism and upregulating the ERK/AKT pathway, European Journal of Pharmacology, Volume 921, 2022, 174885, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2022.174885.

Sofrona E, Tziveleka LA, Harizani M, Koroli P, Sfiniadakis I, Roussis V, Rallis M, Ioannou E. In Vivo Evaluation of the Wound Healing Activity of Extracts and Bioactive Constituents of the Marine Isopod Ceratothoa oestroides. Mar Drugs. 2020 Apr 18;18(4):219. doi: 10.3390/md18040219. PMID: 32325719; PMCID: PMC7230750.

Anti-Inflammatory

Marine compounds, including polysaccharides and peptides, have wide-ranging anti-inflammatory properties.

Xu J, Yi M, Ding L, He S. A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000-2018. Mar Drugs. 2019 Nov 9;17(11):636. doi: 10.3390/md17110636. PMID: 31717541; PMCID: PMC6891400.

Elbandy M. Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders. Molecules. 2022 Dec 20;28(1):2. doi: 10.3390/molecules28010002. PMID: 36615197; PMCID: PMC9822486.

Subramanya SB, Chandran S, Almarzooqi S, Raj V, Al Zahmi AS, Al Katheeri RA, Al Zadjali SA, Collin PD, Adrian TE. Frondanol, a Nutraceutical Extract from Cucumaria frondosa, Attenuates Colonic Inflammation in a DSS-Induced Colitis Model in Mice. Marine Drugs. 2018; 16(5):148. https://doi.org/10.3390/md16050148

Anti-Microbial

The marine species in Natural Marine Extract have developed unique compounds to defend against infection from microbes found in their environment. White papers have shown that these antimicrobial properties are beneficial to human health.

Hughes CC, Fenical W. Antibacterials from the sea. Chemistry. 2010 Nov 8;16(42):12512-25. doi: 10.1002/chem.201001279. PMID: 20845412; PMCID: PMC3071975.

Kurhekar JV. Antimicrobial lead compounds from marine plants. Phytochemicals as Lead Compounds for New Drug Discovery. 2020:257–74. doi: 10.1016/B978-0-12-817890-4.00017-2. Epub 2020 Jan 24. PMCID: PMC7153345.

Karthikeyan A, Joseph A, Nair BG. Promising bioactive compounds from the marine environment and their potential effects on various diseases. J Genet Eng Biotechnol. 2022 Jan 26;20(1):14. doi: 10.1186/s43141-021-00290-4. PMID: 35080679; PMCID: PMC8790952.

Anti-Cancer

Studies have shown that marine extracts including marine triterpenoids found in Natural Marine Extract show anti-cancer properties.

Li Y-X, Himaya SWA, Kim S-K. Triterpenoids of Marine Origin as Anti-Cancer Agents. Molecules. 2013; 18(7):7886-7909. https://doi.org/10.3390/molecules18077886

Ru R, Chen G, Liang X, Cao X, Yuan L, Meng M. Sea Cucumber Derived Triterpenoid Glycoside Frondoside A: A Potential Anti-Bladder Cancer Drug. Nutrients. 2023 Jan 11;15(2):378. doi: 10.3390/nu15020378. PMID: 36678249; PMCID: PMC9861588.

Lee CG, Kwon HK, Ryu JH, Kang SJ, Im CR, Ii Kim J, Im SH. Abalone visceral extracts inhibit tumor growth and metastasis by modulating Cox-2 levels and CD8+ T cell activity. BMC Complement Altern Med. 2010 Oct 20;10:60. doi: 10.1186/1472-6882-10-60. PMID: 20961430; PMCID: PMC2972231.

Chaudhry GE, Islamiah M, Zafar MN, Bakar K, Aziz N, Saidin J, Sung YY, Tengku Muhammad TS. Induction of Apoptosis by Acanthaster planci sp., and Diadema setosum sp., Fractions in Human Cervical Cancer Cell Line, HeLa. Asian Pac J Cancer Prev. 2021 May 1;22(5):1365-1373. doi: 10.31557/APJCP.2021.22.5.1365. PMID: 34048163; PMCID: PMC8408404.